Non-steroidal anti-inflammatory drugs are often used analgetics in dentistrybecause of their analgetic and anti-inflammatory effects. Oral health care providers should know their interactions and side-effects meticulously. The automatic prescription of another analgetic just to avoid the side-affects is not always an option, since then the specific properties of NSAID’s are missed. A correct patient information, specific medical controls, a combination with other medication or other measures may provide for a safe use of NSAID’s. In case of healthy patients younger than 70 years of age and a medication time less than two weeks seldom specific measures are indicated.