The surgical and prosthetic aftercare of craniofacial prostheses supported by endosseous implants were registered in patients treated with implant-retained craniofacial prostheses in a university clinic during the last two decades. Aftercare was registered during the period from implant placement until the last follow-up visit. Implant survival rate was 95,2% in non-irradiated and 78,8% in irradiated bone. Discoloration of the silicon material, becoming loose of the acrylic clip carrier from the silicone, rupture of the silicone, and ill-fitting of the prosthesis were main reasons for fabrication of a new craniofacial prosthesis.