Dental practitioners as well as general practitioners are frequently confronted with patients complaining of pain in the orofacial region. Diagnosing these pains often poses a challenge to the clinician. Currently, the diagnosis of orofacial pains is biaxial. In determining a diagnosis, it is important to consider, in addition to the condition which is causing the pain (axis Idiagnosis), the impact of the pain on the patient’s ability to function (axis IIdiagnosis). The compilation of a thorough medical history represents the most important diagnostic tool and basis for clinical examination. Based on the axis I-diagnosis several treatment options are suggested; the strategy for managing the pain is, however, largely determined by the axis II-diagnosis.