A 20-year-old man presented with multiple intra-oral fistulae in the anterior part of the mandible. The patient was diagnosed with secondary osteomyelitis. Microbiologic survey revealed positive cultures for Staphylococcus aureus, Haemophilus para-influenzae and alpha-haemolytic streptococci. After sequestrectomy and decortication, the mobile teeth were splinted. The patient was treated with intravenous antibiotics, followed by long-term oral antibiotics. Complete healing was achieved.