In dentistry studies concerning systemic effects of dental materials are scarce. However, in vitro research showed that from each metal-containing restoration ions will be released. These metal ions can be spread locally but also in the entire human body and initiate an immune response. Nickel and palladium are recognized as the most allergenic elements. In this manuscript a method for evaluation of the alloy composition is described which may help dentists to reveal the relation between alloy composition and health effects.