Cocaine has a strong vasoconstrictive effect. It is seldom used in modern medicine. The only known regular application is by otorhinolaryngologists as a decongestive for the nasal mucosa. In a pilot study it was measured if the amount of blood loss in patients who underwent a Le Fort-I osteotomy in combination with a bilateral sagittal split osteotomy was reduced by application of a combination of cocaine and adrenalin on the bottom of the nose during surgery. The results of the pilot study suggested a positive effect of the combination of cocaine and adrenalin on blood loss. This preliminary finding seems to justify further study.