A dentist referred a 32-year-old man with the Prader-Willi syndrome to a center for special dental care because of the poor cooperation of the patient, progressive toothwear and advanced palatal trauma. The dental problems were, among others, caused by the disto-relation (Class II-2), a poor oral hygiene, the frequency of sugar intake, oesophageal reflux and a strongly reduced salivary pH of 5.5. Treatment of the dentition was established by minimal invasive and adhesive dentistry.