A 12-year old boy was referred to an orthodontist. During examination of his dental status a swelling was seen at the right side of his palate. Further examination demonstrated a central giant cell granuloma. This is a rare benign tumor that often causes local destruction of the bone and displacement of teeth. Surgical curettage of these large central giant cell granulomas gives mulilations of the jaws and loss of teeth and tooth germs. Furthermore, it has a high recurrence rate. Therefore, calcitonin was chosen as an alternative therapy.